Preliminary phytochemical analysis of leaf powder extracts. Warburgia ugandensis bioassay of different plant parts concerning. This data set contains scores for 185 loci for 100 individuals of the warburgia ugandensis tree species a medicinal tree species native to eastern africa. Its allelophathic nature can drastically reduced the crop production and aggressive dominance of this weed threatens. Pdf phytochemical analysis of warburgia ugandensis sprague. Warburgia ugandensis, sprague, also known as the east african greenheart, a canallaceae, is a species of evergreen tree common to east african forests7. Warburgia ugandensis sprague family canellaceae, commonly referred to as east african greenheart pepperbark tree is widely distributed in the lowland rainforests and upland dry evergreen forests of eastern and southern africa 1. Safety and efficacy of prunus africana and warburgia. Extracts of warburgia ugandensis have been reported to show some antimalarial properties in animal models. Phytochemical tests in our laboratories indicated the presence of tannins. Abstract arun arora, deepak mahapatra, fourier transform infrared spectroscopy analysis of few medicinal plants of. Warbugia ugandensis kenya neem foundation herbal clinic. In vitro effects of warburgia ugandensis, psiadia punctulata and chasmanthera dependens on leishmania major promastigotes. Chromatography of extracts of warburgia ugandensis stem bark afforded compound 49169k, which was characterized as the sesquiterpine muzigadial by 1 hnmr spectroscopy, which did not show antibacterial activity but had.
Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83 nlb144 and infected macrophages in vitro. Kadu cac, schueler s, konrad sh, muluvi gm, eyogmatig o, muchugi a, williams vl, ramamonjisoa l, kapinga c, foahom b, katsvanga c, hafashimana d, obama c and. A comparative study of the stembark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w. Petiole bases and shoot tips were used as explants. Warburgia ugandensis extracts were generally more toxic table 2. Applications of phytochemical and in vitro techniques for. Phytochemistry and pharmacological studies on solanum. Warburgia ugandensis, also known as ugandan greenheart, is a species of evergreen tree native to africa. Warburgia ugandensis is a multipurpose tree which is highly beneficial for its pharmaceutical properties and is. Ms, drimane sesquiterpenes, sugars and sugar alcohols, were compared with bacterial and fungal endophyte communities trflp, dna clones, qpcr in leaves and roots of the pepper bark tree, warburgia ugandensis canellaceae. Abraham abebe wube1, simon gibbons2, kaleab asres3, bernhard streit1, michael adams1, rudolf bauer1, franz bucar1 1 institute of pharmaceuticalsciences, department of pharmacognosy, university graz, of graz, austria.
Pdf warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued. Bioassayguided studies on the cytotoxic and in vitro. Sesquiterpenes from warburgia ugandensis and their. Warburgia ugandensis sprague canellaceae extracts from different populations across the kenyan rift valley abuto john otieno b. Frontiers antimicrobial drimane sesquiterpenes and their. The stem bark has been widely used in east african ethnomedicine for the treatment of stomachache, constipation, toothache, cough, fever, muscle pains, weak joints and general body pains kokwaro, 1976, watt and breyerbrandwijk, 1962. Warburgia ugandensis health effects and herbal facts. The spatial scale of influence may increase when plant defense compounds are secreted in soil, affecting colonization by mycorrhizal and soil fungi stinson et al. In subsaharan africa, chronic kidney disease ckd is being recognized as a noncommunicable disease ncd with high morbidity and mortality.
The wood is resistant to insect attack and very strong. Warburgia ugandensis sprague, which belongs to a member of canellaceae family, is a small evergreen tree distributed in eastern and southern africa. Phytochemical analysis of warburgia ugandensis sprague using. Wood anatomy of pleodendron costaricense canellaceae. In silico validation of two antiparasitic acetogenins 26 sl 32 mulaa, francis j. In countries like tanzania, people access many sources, including traditional medicines, to meet their healthcare needs for ncds, but little is known about traditional medicine practices among people with ckd. Warburgia ugandensis is an evergreen tree with a spreading, rounded crown. It has a reputation for facilitating blood circulation and dispersing blood stasis. Stuhlmann collected warburgia from mpizi near pangani in the then tanganyika and named it w. Diversity in the phytochemical profiles of warburgia. Kenya,ethiopia and some parts of western africa the wood is resistant to insect attack and very strong.
This species has its habitat encroached and this has led to a notable decrease in its population size to the level that warrant some conservation efforts. Although locally common in some areas, the populations of this species have been wiped out in many areas due to the use of its bark by traditional healers for medicinal purposes against asthma, maralia and other ailments as well as skin cream. Various parts fruit, leaves and roots are being in use for the isolation of a wide range of compounds. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa stem bark powder is known to be active against microbes olila et al. Pdf diversity in the phytochemical profiles of warburgia. It was commonly used for the yoke pole of oxwagons, the disselboom. Warburgia ugandensis is commonly known as east african green woodgreenheartpepper bark tree and it is in the family canellaceae 23. Phytochemical analysis of warburgia ugandensis sprague. In vitro 12shete and leukotriene metabolism inhibitory.
Diversity in the phytochemical profiles of warburgia ugandensis. In southern africa, the medicinal plant warburgia salutaris is commonly used for the treatment of inflammatory and other diseases. Acetylugandensolide and antimicrobial properties of warburgia ugandensis extracts and isolates against sweet potato pathogens. This study describes an efficient regeneration protocol. Jan 22, 2019 warburgia ugandensis sprague is a woody species in the family canellaceae and an important source of medicines in africa. The tree species also occurs in secondary bushlands, grasslands and termitaria. Antimicrobial and cytotoxic activities of fresh leaf extracts. Gane sent a warburgia specimen from the present tanzania to verdcourt 1954 that had foliage similar to w.
Commercial maize has been selectively bred to produce high quantities of. Sabinet a phytochemical basis for the potential use of. This weed is considered to be a cause of a spectrum of clinical patterns. Screening of extracts of zanthoxylum chalybeum and warburgia. The ability of warburgia salutaris extracts to protect. In vitro effects of warburgia ugandensis, psiadia punctulata. Commercial maize has been selectively bred to produce high quantities of defense compounds, the benzoxazinoids bxs. Phytochemistry solanum torvum has been extensively explored for its chemical constituents.
Phytochemical analysis of warburgia ugandensis sprague using fourier transform infrared ftir spectroscopy. Ten individuals each were assessed from two locations east and west of the great rift valley, kenya, africa, which differed in humidity and. Canaleaceae, also known as the east african greenheart, is a species of evergreen tree native to africa and a highly. Antimicrobial and cytotoxic activities of fresh leaf extracts of warburgia ugandensis z. Pdf warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. Molecules free fulltext ugandenial a, a new drimanetype. Initially, verdcourt thought that the specimen was conspecific with w.
International journal of pharmacognosy and phytochemical research 2014. Abstract warburgia ugandensis is a highly valued medicinal tree within east africa which is overexploited for its medicinal use among. In vitro 12shete and leukotriene metabolism inhibitory activity of sesquiterpenes of warburgia ugandensis. Warburgia ugandensis in plasmodium berghei infected mice ournal of pharmacognosy and phytochemistry issn. Plant extracts from warburgia ugandensis sprague family. Traditional medicine practices among community members with. The presence of biologically active drimane sesquiterpenoid lactone constituents in the leaves, here demonstrated, provides the rational basis for their substitution for bark in ethnomedicine. Evidence for alteration of fungal endophyte community. Dragons blood is the name given to a deep red resin obtained from a variety of plant sources. Most of the biological activities are attributed to the drimane sesquiterpenoids, including polygodial, warburganal, muzigadial, mukaadial and ugandensial, flavonoids and miscellaneous compounds present in the various species. Warburgia canellaceae species have a long history of ethnomedicinal uses in east, central and southern africa. Warburgia bark has been commonly used as traditional medicines for the treatment of gastrointestinal disorders, cold, cough and sore throat, fever, malaria, respiratory and odontological problems in african countries.
Due to overexploitation for its medicinal uses, the. Warburgia ugandensis water extracts and fraction 27163d also showed antifungal activity against candida albicans. Warburgia ugandensis bioassay of different plant parts concerning the antimicrobial. Warburgia ugandensis kenyatta university repository. A comparative study of the stem bark drimane sesquiterpenes and leaf volatile oils of warburgia ugandensis and w.
The cytotoxicity of the drugs on balbc peritoneal macrophage cells was insignificant as compared to the highly toxic drug of choice pentostam. The stem and roots of warburgia ugandensis sprague are used as expectorant, for the common cold and against fever, malaria, stomachache, constipation and diarrhea 1, 2. An efficient callusbased in vitro regeneration protocol for. One new drimanetype sesquiterpenoid, named ugandenial a 1, was isolated from the ethyl acetate extract of the bark of warburgia ugandensis canellaceae together with eight known drimanetype sesquiterpenoids. Warburgia ugandensis phytochemical research projectifs research. Variation in antimicrobial activity of warburgia ugandensis. Menispermaceae were tested for activity on leishmania major promastigotes strain iduke83. In traditional chinese medicine, this resinous medicine is commonly prescribed to invigorate blood. The sugar alcohol mannitol 3% has been reported as present gr1. I56230552011 a thesis submitted in partial fulfillment of the requirements for the award of the degree of master of science biotechnology in the school of pure and applied. Warburgia ugandensis isa highly valuedmedicinal tree within east africa which is overexploited for its medicinal use among many communities.
Polygodial, an antifungal potentiator journal of natural. Canellaceae is an important, overexploited african ethnomedicinal plant threatened with extinction in the wild. Warburgia ugandensis sprague canellaceae, which is commonly known as zogdom in amharic, is characterized by its bitter and peppery taste. Pdf toxicology, phytochemistry, bioactive compounds and. A drimane sesquiterpenoid lactone from warburgia salutaris. The bark of warburgia ugandensis is widely used as a herbal medicine in kenya and africa. Parthenium hysterophorus, members of the asteraceae family is a noxious weed in america, asia, africa and australia. Kowalski and van staden 2001 and prunus africana are exploited, while the rhizome of alepidea amatymbica is used cunningham 1993. Antibacterial and antifungal activities of extracts of. Alice njeri muchugi 5 on rooting and shoot formation of warburgia ugandensis stem cuttings african journal of plant science vol. Warburgia is a genus of plant in family canellaceae described as a genus in 1895. Warburgia ugandensis bioassay of different plant parts. Warburgia ugandensis sprague family canellacea commonly known as ugandan greenheart or pepper bark tree, is a highly valued medicinal plant in traditional medicine with a broad spectrum of antimicrobial activity whose parts especially the leaves and stem bark have for long been used in the treatment and management of many diseases and health conditions such as stomachache, cough, toothache. This tree species is also found in india and china 1, 3.
Warburgia ugandensis, also known as uganda greenheart, is a species of evergreen tree native to africa. Warburgia ugandensis medicinal herb used for the treatment of diabetes, malaria and pneumonia in kisii region, southwest kenya global journal of pharmacology. The resin extracted from stems of dracaena cochinchinensis is one such source of dragons blood. A phytochemical basis for the potential use of warburgia salutaris pepperbark tree leaves in the place of bark article pdf available january 2001 with 456 reads how we measure reads. Most of the african counties in which the plant species is found include. Warburgia ugandensis sprague is one of the most utilized medicinal plants in kenya. A model for antimalarial drugs discovery 24 sl 30 robert byamukama cycloartane triterpenes from the leaves of neoboutonia macrocalyx l. Pdf a phytochemical basis for the potential use of.
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